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1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute,Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation,Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering,Southeast University
Chapters
- 00:05Title
- 00:55Donor and Recipient HLA Sequence Bioinformatic Analysis and Custom Array Synthesis
- 03:19Probe the Pre- and Post-Transplant Sera
- 05:06Data Acquisition and Analysis
- 06:11Results: Representative Recipient anti-Donor HLA Alloantibody Detection
- 07:36Conclusion
Incompatibilités dans les séquences antigen (HLA) leucocytaire humain entre donneur d’organe et de paires de destinataire sont la principale cause de rejet humoral dans la transplantation d’organes. Nous présentons ici l’utilisation de tableaux d’antigène personnalisés qui sont basées sur les séquences de HLA de donateurs individuels pour sonder des allo-anticorps d’anti-donneurs HLA chez des receveurs d’organes.
