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1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology,Taipei Medical University
Chapters
- 00:05Title
- 01:21Preparation of Micro-osmotic Pump Infusion Systems
- 02:41Intracerebral Ventricular Surgery – Implantation of the Micro-osmotic Pump
- 04:15Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
- 06:04Results: Glucose Metabolism and Insulin Signal Activation
- 07:27Conclusion
Denne protokollen studier rollen chemokine (C-C motiv) ligand 5 (CCL5) i hypotalamus ved å levere en antagonist, MetCCL5, inn i musen hjernen ved hjelp av en mikro-osmotisk pumpe hjernen infusjonssystemet. Denne forbigående hemming av CCL5 aktivitet avbrutt hypothalamus insulin signalnettverk, som fører til glukose intoleranse og eksterne systemisk insulinfølsomhet.
