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1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology,Taipei Medical University
Chapters
- 00:05Title
- 01:21Preparation of Micro-osmotic Pump Infusion Systems
- 02:41Intracerebral Ventricular Surgery – Implantation of the Micro-osmotic Pump
- 04:15Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
- 06:04Results: Glucose Metabolism and Insulin Signal Activation
- 07:27Conclusion
Este protocolo estuda o papel do ligante de chemokine (C-C motif) 5 (CCL5) no hipotálamo, entregando um antagonista, MetCCL5, dentro do cérebro de rato usando um sistema de infusão de cérebro de bomba micro-osmótica. Esta inibição transitória de CCL5 atividade interrompida hipotalâmica insulina sinalização, levando à intolerância à glicose e a sensibilidade periférica à insulina sistêmica.
