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JoVE Journal Neuroscience
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
 

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Article DOI: 10.3791/56455-v • 07:30 min • November 9th, 2017
November 9th, 2017 •
1, 1, 1, 1, 1, 1
1Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne

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요약
Automatic Translation

This report outlines a simple approach to successfully induce experimental autoimmune neuritis (EAN) using the myelin protein zero (P0)180-199 peptide in combination with Freund's complete adjuvant and pertussis toxin. We present a sophisticated paradigm capable of accurately assessing the extent of functional deficits and neuropathology that occur in this EAN.

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Keywords: Experimental Autoimmune Neuritis EAN Mouse Model Peripheral Neuropathy Motor Function Assessment Pertussis Toxin Mycobacterium Tuberculosis Complete Freund's Adjuvant Gait Function Imaging System Clinical Scoring
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