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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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신경과학
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

DOI:
10.3791/56569-v

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07:02 min

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February 11, 2019

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, , , , , ,
1Centre for Human Drug Research (CHDR), Leiden

Chapters

  • 00:04Title
  • 00:36Adaptive Tracking Test
  • 01:35Saccadic Eye Movement and Smooth Pursuit Test
  • 03:28Visual Analog Scale, Body Sway and Visual Verbal Learning Test
  • 05:32Results: Effect of Placebo, Mecamylamine, and Scopolamine on the Adaptive Tracking Test in Healthy Young Males
  • 06:08Conclusion

Summary

자동 번역

자동 번역

A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.

Tags

PharmacodynamicCentral Nervous SystemCholinergic DrugsEarly Phase Drug DevelopmentNeuropsychologicalNeurophysiologicalTest BatteryRepeated MeasurementsConcentration Effects RelationshipsDose EscalationComputerized TestEye ElectrodesEEGSubject Performance

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