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体内在肿瘤微环境中 pH 值、 pO₂、氧化还原状态、磷酸盐和谷胱甘肽浓度的 EPR 评价

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In Vivo EPR Assessment of pH, pO₂, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment

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体内在肿瘤微环境中 pH 值、 pO₂、氧化还原状态、磷酸盐和谷胱甘肽浓度的 EPR 评价

DOI:

10.3791/56624-v

•

10:46 min

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March 16, 2018

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Andrey A. Bobko², Timothy D. Eubank³, Benoit Driesschaert², Valery V. Khramtsov²

¹In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center,West Virginia University, ²Department of Biochemistry,West Virginia University School of Medicine, ³Department of Microbiology, Immunology & Cell Biology,West Virginia University School of Medicine

Chapters

00:04Title
01:20Probe Synthesis and Calibration
05:42Probe Delivery for In Vivo Functional Measurements
07:18In Vivo Functional Measurements
08:09Results: EPR Assessment in the Tumor Microenvironment
10:04Conclusion

Summary

자동 번역

利用可溶性基团和三苯三苯探针对低场 (L 波段, 1.2 GHz) 电子顺磁共振进行了分析, 以评估乳腺癌小鼠模型中肿瘤微环境中生理上的重要参数。

Tags

Keywords: In Vivo EPR Tumor Microenvironment Physiological Parameters Oxygen Tension Redox Status Phosphate Glutathione Noninvasive Assessment Paramagnetic Probes Oxygen-sensitive Probe PH And Redox Probe Calibration EPR Spectroscopy

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