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Chapters
- 00:04Title
- 00:48Bleomycin and Cell Bolus Treatment
- 03:31Engrafting Lung Adenocarcinoma Cell Lines
- 05:04Image Analysis to Monitor Tumor Growth
- 06:33Results: Analysis of Bleomycin Pre-treatment in Athymic Mice
- 07:58Conclusion
We describe a method to significantly enhance orthotopic engraftment of lung cancer cells into the murine lungs by pre-conditioning the airways with injury. This approach may also be applied to study stromal interactions within the lung microenvironment, metastatic dissemination, lung cancer co-morbidities, and to more efficiently generate patient derived xenografts.
