Journal
/
생체공학
/
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
JoVE 신문
생체공학
This content is Free Access.
JoVE 신문 생체공학
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

DOI:
10.3791/56760-v

•

10:38 min

•

January 15, 2018

•

, , , ,
1Department of Chemical Engineering,Northeastern University, 2Nanomedicine Science and Technology Center,Northeastern University, 3Department of Physics,Northeastern University, 4Departments of Bioengineering,Northeastern University, 5Department of Neuroscience,Albert Einstein College of Medicine

Chapters

  • 00:05Title
  • 00:38Synthesis of Polyethylene Glycol-coated Gold Nanoparticles (PEG-AuNPs)
  • 03:13Conjugation of Fluorophores onto the PEG-AuNP NH2 Groups
  • 04:56Characterization of Fluorescent PEG-AuNPs
  • 08:46Results: Size and Biocompatibility of THPC-coated and Fluorescent PEG-AuNPs
  • 10:19Conclusion

Summary

자동 번역

자동 번역

We describe a method of synthesizing biocompatible 10-nm gold nanoparticles, functionalized by coating poly-ethylene glycol onto the surface. These particles can be used in vitro and in vivo for delivering therapeutics to nanoscale cellular and extracellular spaces that are difficult to access with conventional nanoparticle sizes.

Tags

Keywords: Gold NanoparticlesPolymer CoatingFunctionalizationEndothelium TargetingDrug DeliveryBiocompatibilityFluorescence ImagingTHPCChloroauric AcidPEGDialysisLyophilization

Article

Embed

플레이리스트에 추가

Usage Statistics

Related Videos

check_url/kr/56760?article_type=v

Synthesis, Assembly, and Characterization of Monolayer Protected Gold Nanoparticle Films for Protein Monolayer Electrochemistry
check_url/kr/56760?article_type=v

Gold Nanostar Synthesis with a Silver Seed Mediated Growth Method
check_url/kr/56760?article_type=v

Self-reporting Scaffolds for 3-Dimensional Cell Culture
check_url/kr/56760?article_type=v

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
check_url/kr/56760?article_type=v

A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
check_url/kr/56760?article_type=v

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
check_url/kr/56760?article_type=v

Manufacture and Drug Delivery Applications of Silk Nanoparticles
check_url/kr/56760?article_type=v

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
check_url/kr/56760?article_type=v

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
check_url/kr/56760?article_type=v

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications

Read Article