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雄激素依赖性和去势抗性前列腺癌的荧光自体小鼠模型

JoVE 신문
암 연구학

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JoVE 신문 암 연구학

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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雄激素依赖性和去势抗性前列腺癌的荧光自体小鼠模型

DOI:

10.3791/57301-v

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07:25 min

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March 06, 2018

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Jonathan F. Anker, Hanlin Mok, Anum F. Naseem, Praveen Thumbikat*^1,3, Sarki A. Abdulkadir*^1,2,3

¹Department of Urology,Northwestern University Feinberg School of Medicine, ²The Robert H. Lurie Comprehensive Cancer Center,Northwestern University Feinberg School of Medicine, ³Department of Pathology,Northwestern University Feinberg School of Medicine

Chapters

00:05Title
00:59Intra-prostatic Injection
04:37Results: Representative Orthotopic Murine Prostate Tumor Analyses
06:17Conclusion

Summary

자동 번역

本协议的目的是证明前列腺癌细胞内注射, 随后阉割。在临床相关的肿瘤微环境和免疫宿主的背景下, 应用雄激素依赖性和抗去势前列腺癌的原位前模型是研究该病的关键。

Tags

Bioluminescent Fluorescent Orthotopic Syngeneic Murine Prostate Cancer Androgen-dependent Castration-resistant Intra-prostatic Injection Tumor Microenvironment Genetic Modification Orthotopic Tumor Therapy Mouse Seminal Vesicle Anterior Prostate Lobe Matrigel Cancer Cell Solution 28-gauge Needle

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