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Rottemodel af udbredt cerebral kortikal demyelinering induceret af en intracerebral injektion af proinflammatoriske cytokiner
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신경과학
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Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Rottemodel af udbredt cerebral kortikal demyelinering induceret af en intracerebral injektion af proinflammatoriske cytokiner

DOI:
10.3791/57879-v

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09:46 min

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September 21, 2021

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, , , , , ,
1Research Unit of Experimental Neurotraumatology, Department of Neurosurgery,Medical University Graz, 2Department of Neurology,Medical University Graz, 3Centre for Molecular Medicine, Department of Clinical Neuroscience,Karolinska Institutet, 4Division of Vascular Biology, Department of Medical Biochemistry and Biophysics,Karolinska Institutet

Chapters

  • 00:05Introduction
  • 01:15Catheter Implantation
  • 04:39Immunization
  • 05:57Intracerebral Cytokine Injection
  • 07:16Results: PLP Immunoreactivity in Coronal Brain Sections
  • 08:52Conclusion

Summary

자동 번역

자동 번역

Protokollen præsenteret her tillader reproduktion af en udbredt grå stof demyelination af begge kortikale halvkugler i voksne mandlige Dark Agouti rotter. Metoden består af intracerebral implantation af et kateter, subklinisk immunisering mod myelin oligodendrocyt glycoprotein og intracerebral injektion af en proinflammatorisk cytokinblanding gennem det implanterede kateter.

Tags

RatCerebral CortexDemyelinationPro-inflammatory CytokinesMultiple SclerosisCatheter ImplantationStereotactic SurgeryCortical InflammationGray Matter DemyelinationAnchor Screws

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