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Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
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Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
DOI:

07:48 min

January 07, 2019

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Chapters

  • 00:04Title
  • 00:47Arginine Glycine Aspartate (RGD)-Peptide Radiolabeling
  • 02:42In Vitro Cellular Uptake and Serum Stability
  • 04:17Lipophilicity Determination, Tumor Model Preparation, In Vivo Quantification, and Ex Vivo Biodistribution
  • 06:05Results: Representative 68Ga-RGD-peptide Purification, Radiochemical Purity, and In Vivo Imaging and Ex Vivo Biodistribution Analyses
  • 07:04Conclusion

Summary

자동 번역

The αvβ3 integrin is a type of adhesion protein that is highly expressed on activated endothelial cells undergoing angiogenesis. Thus, evaluating the integrity of the integrin is of great interest in oncology. Here, we introduce a method to prepare 68Ga-labeled radiopeptides and a method to assess its biological effectiveness.

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