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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

DOI:
10.3791/58291-v

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15:04 min

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January 19, 2019

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, , , , ,
1Centre de Recherche en Cancérologie et Immunologie Nantes Angers (CRCINA), Institut national de la santé et de la recherche médicale (INSERM), Université d’Angers, Université de Nantes, Nantes, France, 2Service de chirurgie pédiatrique,Centre hospitalier universitaire (CHU) de Nantes, Nantes, France, 3Unité de Formation et Recherche (UFR) des Sciences Pharmaceutiques et Biologiques,Université de Nantes, Nantes, France

Chapters

  • 00:00Title
  • 01:38Evaluation of the Drug Interaction between mAb 8B6 and Topotecan in vitro
  • 07:35Generation of Human IMR5 Neuroblastoma Xenografts in NSG Mice
  • 12:18Representative Results
  • 14:09Conclusion

Summary

자동 번역

자동 번역

This protocol describes how to assess synergism between an anticancer antibody and antineoplastic drugs in preclinical models by using the combination index equation of Chou and Talalay.

Tags

Anticancer AntibodyAntineoplastic DrugsCombination IndexSynergismImmunotherapyChemotherapyMonoclonal AntibodyNeuroblastomaTopotecanIn VitroIn VivoCell CultureXenograft Model

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