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Neuroscience

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JoVE Journal Neuroscience
Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia
 

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

Article DOI: 10.3791/58576-v • 07:18 min • November 9th, 2018
November 9th, 2018 •
1, 2,3, 3, 3, 4, 3
1Neuroscience Discovery, Janssen Pharmaceutical Company of Johnson & Johnson, Belgium, 2Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, The Netherlands, 3Janssen Prevention Center, Janssen Pharmaceutical Company of Johnson & Johnson, The Netherlands, 4Neuroscience Discovery, Janssen Pharmaceutical Company of Johnson & Johnson, Pennsylvania

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요약
Automatic Translation

Here we describe a cell-based assay to quantitatively assess tau uptake by microglia with the aim of creating an investigational tool to better characterize the mechanisms of action of anti-tau antibodies.

Tags

Cell-based Assay Antibody-mediated Tau Clearance Microglia Alzheimer's Disease Therapeutic Anti-Tau Antibodies Pathology Reduction Aggregated Tau Uptake Mechanism Of Action Investigational Tool BV-2 Cells Trypsin EDTA Culture Medium Heparin Cell Suspension Well Tissue Culture Plate PH Dye-Tau Aggregates Serum Free Medium Antibody Dilution Plate
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