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一种评价金黄色葡萄球菌感染先天免疫反应的小鼠模型

JoVE 신문
면역학 및 감염병학

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JoVE 신문 면역학 및 감염병학

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

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一种评价金黄色葡萄球菌感染先天免疫反应的小鼠模型

DOI:

10.3791/59015-v

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09:15 min

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February 28, 2019

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Leif S. Anderson, Mack B. Reynolds, Kathryn R. Rivara, Lloyd S. Miller, Scott I. Simon

¹Department of Biomedical Engineering,University of California Davis, ²Department of Dermatology,Johns Hopkins University School of Medicine

Chapters

00:04Title
00:38Bacterial Preparation and Quantification
02:44Excisional Skin Wounding
03:50Staphylococcus aureus Inoculation
04:44In Vivo Bioluminescent and Fluorescence Imaging
06:02Bioluminescent and Fluorescence Image Analysis
06:45Results: LysM-EGFPMyD88-/- Mice are More Susceptible to S. aureus Infection Than LysM-EGFP Mice
08:30Conclusion

Summary

자동 번역

介绍了一种实时检测小鼠皮肤损伤和金黄色葡萄球菌感染的先天免疫反应的方法。通过将 lysm-egfp 小鼠 (具有荧光中性粒细胞) 与 lysm-egfp 杂交免疫缺陷小鼠株进行比较, 提高了对感染的认识, 并提出了对抗感染的方法。

Tags

Keywords: Mouse Model Staphylococcus Aureus Infection Innate Immune Response Bioluminescence Bacterial Burden Neutrophil Response Longitudinal Monitoring Excisional Skin Wounding Bacterial Inoculation Colony-forming Units

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