Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of &#945;-Imino &#947;-Lactones and Alkylidene Pyrazolones

Yani Zhou; Nannan Chen; Yaping Cheng; Xiaoqing Cai

doi:10.3791/59155

/

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

JoVE 신문
화학

JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.

JoVE 신문 화학

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

DOI:

10.3791/59155-v

•

10:17 min

•

February 07, 2019

•

Yani Zhou, Nannan Chen, Yaping Cheng, Xiaoqing Cai

¹School of Basic Medical Sciences,Lanzhou University, ²School of Pharmaceutical Sciences,Sun Yat-sen University

Chapters

00:04Title
01:07Preparation of α-Arylidiene Pyrazolinone Species
06:38Asymmetric Synthesis of Bispirocyclic Compounds
08:00Results: Synthesis and Characterization of Enantiomerically Enriched Bispirocyclic Scaffolds
09:22Conclusion

Summary

자동 번역

Enantiomerically enriched bispiro[γ-butyrolactone-pyrrolidin-4,4'-pyrazolone] skeletons are asymmetrically synthesized through a simple organocatalytic 1,3-dipolar cycloaddition reaction.

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

•

•

•

Chapters

Summary

자동 번역

Tags

Article

Embed

플레이리스트에 추가

Usage Statistics

Related Videos

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Construction of Models for Nondestructive Prediction of Ingredient Contents in Blueberries by Near-infrared Spectroscopy Based on HPLC Measurements

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

The Preparation and Properties of Thermo-reversibly Cross-linked Rubber Via Diels-Alder Chemistry

A Simple and Efficient Protocol for the Catalytic Insertion Polymerization of Functional Norbornenes

Fabrication and Testing of Catalytic Aerogels Prepared Via Rapid Supercritical Extraction

Synthesis of Substrate-Bound Au Nanowires Via an Active Surface Growth Mechanism

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile

Experimental Methods for Efficient Solar Hydrogen Production in Microgravity Environment

Read Article