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在肝炎症和纤维化环境中产生的肝细胞癌的致癌肝细胞诱导正交小鼠模型

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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

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在肝炎症和纤维化环境中产生的肝细胞癌的致癌肝细胞诱导正交小鼠模型

DOI:

10.3791/59368-v

•

00:06 min

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September 12, 2019

•

Xiaoqiang Qi*^1,2,3, Emily Schepers*^1,2, Diego Avella², Eric T. Kimchi², Jussuf T. Kaifi², Kevin F. Staveley-O’Carroll², Guangfu Li^2,3

¹Department of Surgery,University of Missouri-Columbia, ²Ellis Fischel Cancer Center,University of Missouri-Columbia, ³Molecular Microbiology and Immunology,University of Missouri-Columbia

Chapters

00:04Title
00:50Liver Fibrosis and Cirrhosis Induction
01:19T Antigen (T Ag)-Transgenic Hepatocyte Isolation
03:48MTD2 Hepatocyte Inoculation
05:22Results: Representative Progress MTD2 Tumor Development
05:58Conclusion

Summary

자동 번역

在这里，我们描述了一个临床相关的肝癌小鼠模型的发展，概括了肝细胞癌（HCC）的典型免疫特征。

Tags

Hepatocellular Cancer Orthotopic Mouse Model Hepatic Inflammation Fibrosis Tumor Immunology Tumor Microenvironment Liver Cancer Tumor Perfusion Collagenase Digestion Tumor Implantation

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