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Chapters
- 00:04Title
- 00:39Tumor Tissue Processing for Mouse Implantation
- 02:42Tumor Implantation and Injection in Mice
- 04:07Tumor Harvesting for Banking Tissue, Reimplantation, and Experiment Characterization
- 05:30Results: Analysis of Melanoma Patient-Derived Xenograft Models
- 06:18Conclusion
Patient-derived xenograft (PDX) models more robustly recapitulate melanoma molecular and biological features and are more predictive of therapy response compared to traditional plastic tissue culture-based assays. Here we describe our standard operating protocol for the establishment of new PDX models and the characterization/experimentation of existing PDX models.
