/

/

用于筛查绝经后心血管功能障碍的外源雌激素治疗的活体雌激素缺乏小鼠模型

JoVE 신문
생화학

JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.

JoVE 신문 생화학

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Please note that all translations are automatically generated. Click here for the English version.

用于筛查绝经后心血管功能障碍的外源雌激素治疗的活体雌激素缺乏小鼠模型

DOI:

10.3791/59536-v

•

06:18 min

•

August 13, 2019

•

Bing Sun, Yue-zhang Yin, Jing Xiao

¹Institute of Medicinal Plant Development (IMPLAD),Chinese Academy of Medical Sciences & Peking Union Medical College, ²Shandong University of Traditional Chinese Medicine

Chapters

00:05Title
00:52Bilateral Ovariectomy
02:22Body Weight, Total Cholesterol (TC), and Triglyceride (TG) Measurement
03:25Aorta Harvest
04:29Results: Representative Effects of Exogenous Estrogens on OVX Mouse Phenotype and Function
05:46Conclusion

Summary

자동 번역

临床上,更年期妇女雌激素缺乏可能加重脂质紊乱和动脉粥样硬化的发生率。我们通过在apoE-/-小鼠的双背侧切口,通过双边卵巢切除术建立了体内雌激素缺乏模型。小鼠模型适用于绝经后心血管功能障碍的外源雌激素治疗。

Tags

Keywords: Ovariectomy Estrogen Deficiency APOE Knockout Mice Cardiovascular Dysfunction Menopause Arteriosclerosis Exogenous Estrogen Treatments Plasma Cholesterol Triglycerides

Article

Embed

플레이리스트에 추가

Usage Statistics

Related Videos

制备及<em>在体内</em>使用基于活动的探针对<em>ñ</em> -acylethanolamine酸酰胺酶

脑膜分离法<em>体检</em评估亚突触蛋白定位的方法

一种简单的高通量化学筛选方法在秀丽线虫中的应用

Langendorff 灌注后离体小鼠心脏 Polysomes 的动态蛋白质组学及 miRNA 分析

全飞头段耗氧率的测定与解释

自组装的人类蛋白质微阵列中的激酶抑制剂筛选

热通菌膜-双磷酶抑制剂的筛选

使用免疫荧光对患有TNBS诱导克罗恩病的小鼠结肠雌激素受体的可视化

使用基于细胞的雌激素受体对植物雌激素进行筛查β记者分析

将新生儿小鼠心脏巨噬细胞移植到成年小鼠体内

Read Article