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Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery
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Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

DOI:
10.3791/59591-v

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08:38 min

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August 16, 2019

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, , ,
1Service of Adult Intensive Care Medicine, Department of Interdisciplinary Centers and Logistics, Lausanne University Hospital and Faculty of Biology and Medicine,Lausanne University, 2Service of Thoracic Surgery, Department of Surgery and Anesthesiology Services, Lausanne University Hospital and Faculty of Biology and Medicine,Lausanne University

Chapters

  • 00:04Title
  • 00:55Tracheal Cannulation
  • 03:30Left Anterior Descending (LAD) Coronary Artery Ligation
  • 05:48Post-Operative Procedures
  • 06:45Results: Representative Fibrosis and Inflammation in Day 7 Whole Myocardium Extracts
  • 08:05Conclusion

Summary

자동 번역

자동 번역

Herein we describe a surgical procedure showing how to achieve permanent ligation of the left-anterior descending coronary artery in mice. This model is of high relevance to investigate the pathophysiology of myocardial infarction and the concomitant biological processes.

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Keywords: Murine Myocardial Infarction ModelPermanent LigationLeft Anterior Descending Coronary ArteryCardiac BiologyCardiac PhysiologySurgical ProcedureAnesthetized MouseVentilatorTracheal IntubationThoracotomyCoronary Artery Ligation

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