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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

DOI:

10.3791/59920-v

•

06:03 min

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July 15, 2019

•

Jonathan Y. Wang, Chien-Ju Lin, Ching-Hsuan Liu⁴, Liang-Tzung Lin⁵

¹Department of Molecular Biosciences,University of Texas at Austin, ²School of Pharmacy, College of Pharmacy,Kaohsiung Medical University, ³Graduate Institute of Medical Sciences, College of Medicine,Taipei Medical University, ⁴Department of Microbiology and Immunology,Dalhousie University, ⁵Department of Microbiology and Immunology, School of Medicine, College of Medicine,Taipei Medical University

Chapters

00:04Title
00:27Time-of-Drug-Addition
02:25Molecular Docking Analysis
04:06Results: Representative Effects of Small Molecule (CHLA and PUG) Binding Against CVA16 Infectivity
05:33Conclusion

Summary

자동 번역

The goal of the protocol is to illustrate the different assays relating to viral entry that can be used to identify candidate viral entry inhibitors.

Tags

Keywords: Viral Entry Assay Molecular Docking Antiviral Candidates Coxsackievirus A16 RD Cells Plaque-forming Units Methylcellulose Crystal Violet PubChem Protein Data Bank Molecular Program Bio-computing Program

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