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Chapters
- 00:05Title
- 01:04Preparation of Buffers and Eluents
- 02:10Application of the Precursor to the Cartridge
- 03:19Setting up the Manifold for Automated Synthesis
- 04:13Radiosynthesis of [11C]PiB
- 06:46Quality Control Procedures
- 07:35Results: Radiosynthesis of [11C]PiB
- 08:53Conclusion
We report an efficient carbon-11 radiolabeling technique to produce clinically relevant tracers for Positron Emission Tomography (PET) using solid phase extraction cartridges. 11C-methylating agent is passed through a cartridge preloaded with precursor and successive elution with aqueous ethanol provides chemically and radiochemically pure PET tracers in high radiochemical yields.
