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JoVE Journal Cancer Research
Jämföra metastaserande clear cell njurcellscancer modell etablerad i mus njure och på kyckling chorioallantoic membranet
 
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Jämföra metastaserande clear cell njurcellscancer modell etablerad i mus njure och på kyckling chorioallantoic membranet

Article DOI: 10.3791/60314-v • 05:36 min • February 8th, 2020
February 8th, 2020 •
*1, *1, 2, 3, 4, 5, 6, 7, 1, 1,8
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 2Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 3Department of Bioengineering, Hanyang University, 4Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 5Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 6School of Life Sciences, Beijing Normal University, 7Department of Urology, West China Hospital, Sichuan University, 8Department of Urology, David Geffen School of Medicine, University of California, Los Angeles
* These authors contributed equally

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Metastaserande klar cell njurcellscancer är en sjukdom utan en omfattande djurmodell för grundlig preklinisk undersökning. Detta protokoll illustrerar två nya djurmodeller för sjukdomen: den ortopediskt implanterade musmodellen och kycklingchorioallantoic membranmodellen, som båda visar lungmetastasering liknar kliniska fall.

Tags

Cancer Forskning njurcellscancer metastasering djurmodell njurimplantation CAM VHL genborttagning intratumoral heterogenitet
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