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1Department of Pharmacology and Toxicology,University of Louisville, 2Hepatobiology and Toxicology Program,University of Louisville, 3Department of Physiology and Pharmacology,West Virginia University, 4Center for Inhalation Toxicology,West Virginia University, 5Department of Pharmacology and Chemical Biology,University of Pittsburgh, 6Pittsburgh Liver Research Center,University of Pittsburgh, 7Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition,University of Pittsburgh
Chapters
- 00:04Title
- 00:42Experimental Setup and Purified Experimental Diet Acclimatization
- 01:21Vinyl Chloride (VC) Inhalation Exposure System Setup
- 02:17Pre-Exposure Setup
- 03:21Exposure Experiment and VC Concentration Validation
- 06:12Post-Exposure
- 07:01Results: Representative Effects of VC on the Enhancement of Diet-Induced Liver Injury
- 08:29Conclusion
Bu protokolün amacı, düşük seviyeli toksik maruziyetin, karaciğer hasarına neden olmayan, daha çok önceden var olan karaciğer hasarını şiddetlendiren bir murine modeli geliştirmekti. Bu paradigma daha iyi insan maruziyeti ve güvenli olarak kabul edilir toksik konsantrasyonlara maruz kalma üzerine meydana gelen ince değişiklikleri özetler.
