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면역학 및 감염병학

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在 Vivo 增强的古特-霍姆调节 T 细胞诱导

JoVE 신문
면역학 및 감염병학

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JoVE 신문 면역학 및 감염병학

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

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在 Vivo 增强的古特-霍姆调节 T 细胞诱导

DOI:

10.3791/60585-v

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08:02 min

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January 22, 2020

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Hongzheng Bi², Samiksha Wasnik, David J. Baylink, Chenfan Liu^3,4, Xiaolei Tang³

¹Division of Regenerative Medicine, Department of Medicine,Loma Linda University, ²Zhengzhou University, ³Department of Veterinary Biomedical Sciences, College of Veterinary Medicine,Long Island University, ⁴Jinan Infectious Disease Hospital,Shandong University

Chapters

00:05Title
00:571-alpha-Hydroxylase and Retinaldehyde Dehydrogenase 2 (RALDH2) Lentivirus (Lenti-CYP-ALDH virus) Preparation
03:04Bone Marrow-Derived Dendritic Cell (BMDC) Generation
05:06BMDC Lenti-CYP-ALDH Transduction
06:00Results: Representative Gut-Homing Regulatory T Cell Induction
07:38Conclusion

Summary

자동 번역

在这里，我们提出了一个方案，在体内扩增的肠道-细胞调节T细胞诱导。在此协议中，树突状细胞被设计成局部产生高浓度活性维生素D（1，25-二羟基维生素D或1，25[OH]2 D）和活性维生素A（视黄酸或RA）的活性。

Tags

Keywords: Gut-homing Regulatory T Cells In Vivo Augmentation Dendritic Cell Generation Lentiviral Transduction Vitamin D Vitamin A Peripheral Immune System

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