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小鼠脚垫接种模型，研究病毒引起的神经炎反应

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면역학 및 감염병학

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JoVE 신문 면역학 및 감염병학

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

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小鼠脚垫接种模型，研究病毒引起的神经炎反应

DOI:

10.3791/61121-v

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09:07 min

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June 14, 2020

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Kathlyn Laval, Carola J. Maturana, Lynn W. Enquist

¹Department of Molecular Biology,Princeton University, ²Princeton Neuroscience Institute,Princeton University

Chapters

00:04Introduction
00:38Mouse Footpad Abrasion
01:15Pseudorabies Virus (PRV) Footpad Inoculation
01:58Tissue Collection
03:32Spinal Cord and Dorsal Root Ganglion (DRG) Extraction
05:49Tissue Homogenization
06:51Results: Representative Viral-Induced Neuroinflammatory Response Evaluation
08:37Conclusion

Summary

자동 번역

脚垫接种模型是描述体内病毒引起的神经炎反应的宝贵工具。特别是，它提供了病毒动力学和相关免疫病理过程在周围神经系统启动的明确评估。

Tags

Keywords: Mouse Footpad Viral Infection Neuroinflammatory Response Peripheral Nervous System Central Nervous System C57BL/6 Mouse Abrasion Virus Inoculation Organ Harvesting Brain Extraction

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