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1Geriatrics Research Education and Clinical Center,Veterans Affairs, 2Division of Gerontology and Geriatric Medicine,University of Washington, 3Department of Neurosurgery,University of Florida, 4Department of Neurosurgery,West Virginia University, 5Division of Pharmaceutical Sciences,University of Cincinnati, 6Central Illinois Neuro Health Sciences, Bloomington, IL, 7Neuro-research, Dallas, TX
Chapters
- 00:04Introduction
- 00:53Installation of the Blast TBI Setup
- 01:34Preparation of Experimental Setup and Induction of Mild TBI in Rodents
- 03:06Exposure of Rodent to Blast Wave and its Recovery
- 03:59Results: Acute In-Vivo Effects of Blast-Induced TBI
- 05:28Conclusion
Presentamos aquí un protocolo de un modelo de onda expansiva para roedores para investigar los efectos neurobiológicos y fisiopatológicos de la lesión cerebral traumática leve a moderada. Establecimos una configuración de sobremesa impulsada por gas equipada con sensores de presión que permiten una generación confiable y reproducible de lesiones cerebrales traumáticas leves a moderadas inducidas por explosiones.
