A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Rianne Haumann; Elvin &#8217;t Hart; Marc  P. P. Derieppe; Helena  C. Besse; Gertjan  J. L. Kaspers; Eelco Hoving; Dannis  G. van Vuurden; Esther Hulleman; Mario Ries

doi:10.3791/61269

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A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

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A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

DOI:

10.3791/61269-v

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08:02 min

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July 16, 2020

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Rianne Haumann*^1,2, Elvin ’t Hart*², Marc P. P. Derieppe, Helena C. Besse, Gertjan J. L. Kaspers², Eelco Hoving, Dannis G. van Vuurden², Esther Hulleman², Mario Ries

¹Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology,Cancer Center Amsterdam, ²Princess Máxima Center for Pediatric Oncology, ³Imaging Division,Utrecht University

Summary

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The blood-brain barrier (BBB) can be temporarily disrupted with microbubble-mediated focused ultrasound (FUS). Here, we describe a step-by-step protocol for high-throughput BBB opening in vivo using a modular FUS system accessible for non-ultrasound experts.

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

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Summary

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