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高通量图像引导立体定向神经导航和聚焦超声系统，用于在啮齿动物中打开血脑屏障

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A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

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高通量图像引导立体定向神经导航和聚焦超声系统，用于在啮齿动物中打开血脑屏障

DOI:

10.3791/61269-v

•

08:02 min

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July 16, 2020

•

Rianne Haumann*^1,2, Elvin ’t Hart*², Marc P. P. Derieppe, Helena C. Besse, Gertjan J. L. Kaspers², Eelco Hoving, Dannis G. van Vuurden², Esther Hulleman², Mario Ries

¹Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Oncology,Cancer Center Amsterdam, ²Princess Máxima Center for Pediatric Oncology, ³Imaging Division,Utrecht University

Summary

자동 번역

血脑屏障（BBB）可以通过微泡介导的聚焦超声波（FUS）暂时中断。在这里，我们描述了一个逐步协议的高通量BBB打开体内使用模块化FUS系统，为非超声专家访问。

Tags

Keywords: High-throughput Image-guided Stereotactic Neuronavigation Focused Ultrasound Blood-brain Barrier Glioma Precision Medicine Drug Evaluation Sonoporation Transducer Stereotactic Platform Animal Preparation

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