JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
1Department of Neuroscience,University of Virginia, 2Department of Radiology,Stanford University, 3Department of Neurology,University of Virginia, 4Global Internship Program,Focused Ultrasound Foundation, 5Department of Medicine,University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery,University of Virginia, 8Center for Brain, Immunology, and Glia,University of Virginia
Chapters
- 00:00Introduction
- 01:36Animal Preparation
- 02:44PING Procedure
- 05:55MRI/FUS Control Room
- 06:35Targeting of FUS
- 07:07Administration of Microbubble, FUS, and Contrast Age
- 07:47Infusion of Quinolinic Acid
- 08:15Results: Imaging and Microscopy
- 10:03Conclusions for PING Method
Het doel van het protocol is om een methode te bieden voor het produceren van niet-invasieve neuronale laesies in de hersenen. De methode maakt gebruik van Magnetic Resonance-guided Focused Ultrasound (MRgFUS) om de bloedhersenbarrière te openen op een voorbijgaande en brandpuntige manier, om een circulerend neurotoxine te leveren aan de hersenen parenchyma.
