JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
1The Graduate Program for Neuroscience,Boston University, 2Department of Biology,Boston University, 3Neurophotonics Center,Boston University, 4Center for Systems Neuroscience,Boston University, 5Research and Early Development,Biogen, 6Department Pharmacology and Experimental Therapeutics,Boston University
Chapters
- 00:04Introduction
- 01:08Preparation for Surgery
- 02:24In Utero Electroporation Surgery
- 04:51Results: Social Behavior in Juvenile and Adult Mice
- 06:34Conclusion
The role of recently discovered disease-associated genes in the pathogenesis of neuropsychiatric disorders remains obscure. A modified bilateral in utero electroporation technique allows for the gene transfer in large populations of neurons and examination of the causative effects of gene expression changes on social behavior.
Tags
Bilateral In Utero ElectroporationGenetic InfluencesRodent BehaviorGene ExpressionNeurological DiseasesGenetic Animal LinesNeurological DisordersGene TransferPathologyNovel TherapiesEmbryo ManipulationGene TransferPregnant DamSurgerySterileDNA SolutionGlass PipetteAnesthesiaAnalgesiaAbdominal Incision
