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Chapters
- 00:04Introduction
- 00:51Generation of Acute Experimental Model of Motor Tic Expression in a Rat
- 02:38Generation of Chronic Experimental Model of Motor Tic Expression in a Rat
- 04:32Implantation of Chronic Model (Osmotic Pump) into the Rat
- 06:19Results: Tic Expression in Both Models
- 07:11Conclusion
We present protocols for generating acute and chronic experimental models of tic expression in freely behaving rats. The models are based on striatal cannula implantation and subsequent GABAA antagonist application. The acute model uses transient injections whereas the chronic model utilizes prolonged infusions via a subcutaneous implanted mini-osmotic pump.
