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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
 

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Article DOI: 10.3791/62101-v • 09:56 min • February 14th, 2021
February 14th, 2021 •
1, 1, 1, 1, 1,2, 3, 1,2
1Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität München, 2German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 3Hannover Medical School, Institute for Neurophysiology

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요약
Automatic Translation

The baroreflex is a heart-rate regulation mechanism by the autonomic nervous system in response to blood-pressure changes. We describe a surgical technique to implant telemetry transmitters for continuous and simultaneous measurement of electrocardiogram and blood pressure in mice. This can determine spontaneous baroreflex sensitivity, an important prognostic marker for cardiovascular disease.

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Keywords: Telemetry ECG Blood Pressure Baroreflex Sensitivity Conscious Mice Cardiovascular Disease Microsurgery Carotid Artery Anesthesia Depilatory Cream Skin Incision Blunt Dissection Parotid Gland Submandibular Gland Trachea
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