/

/

患者源性肿瘤外植体作为预测患者耐药性的"实时"临床前平台

JoVE 신문
암 연구학

JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.

JoVE 신문 암 연구학

Patient-Derived Tumor Explants As a “Live” Preclinical Platform for Predicting Drug Resistance in Patients

Please note that all translations are automatically generated. Click here for the English version.

患者源性肿瘤外植体作为预测患者耐药性的"实时"临床前平台

DOI:

10.3791/62130-v

•

07:42 min

•

February 07, 2021

•

Giuditta Viticchié, Ian Powley, Constantinos Demetriou, James Cooper, Michael Butterworth, Meeta Patel, Naila Abid, Gareth Miles, Lynne Howells, Howard Pringle, Marion MacFarlane, Catrin Pritchard

¹Leicester Cancer Research Center,University of Leicester, ²MRC Toxicology Unit

Chapters

00:04Introduction
00:45Explant Preparation and Drug Treatment
02:12Histological Processing
03:09Training Analysis
06:04Results: Representative Patient-Derived Explant Responses to Tumor Drugs of Interest
07:02Conclusion

Summary

자동 번역

本文描述了在实时的、与患者相关的临床前模型系统中评估肿瘤药物反应的患者来源的外植体的生成、药物治疗和分析方法。

Tags

Patient-derived Tumor Explants Preclinical Platform Drug Resistance Prediction 3D Tumor Context Drug Response Drug Metabolism Pharmacodynamic Biomarkers Organotypic Culture Drug Treatment Formalin Fixation Histological Processing

Article

Embed

플레이리스트에 추가

Usage Statistics

Related Videos

开发和维护的临床前患者来源的肿瘤异种移植模型为新的抗癌疗法的调查

可追踪记者乳腺癌患者来源的移植瘤贴标肿瘤生长和转移的研究

患者衍生的人类泌尿细胞癌和结肠直肠癌肿瘤生长和自发转移的正交异种移植模型

利用血脑肿瘤屏障在盘中进行活体有效载荷传递预测

患者衍生的胰腺癌异质异种移植模型,使用斑马鱼幼虫作为比较药物评估的宿主

在全融合微流体平台中增强患者衍生异种移植物的外体 3D 水凝胶培养物的生存能力

斑马鱼原发性患者衍生肿瘤异种移植物的药物筛选

使用患者源性肿瘤类器官的高通量体外检测

使用宽场活细胞成像进行批量和单类器官分析的多参数肿瘤类器官药物筛选

小鼠患者来源的癌细胞原位植入概括了晚期结直肠癌

Read Article