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表面活性剂耗竭与有害通风相结合导致急性呼吸窘迫综合症 (ARDS) 的可重复模型
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JoVE 신문 의학
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
DOI:

06:22 min

April 07, 2021

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Chapters

  • 00:05Introduction
  • 00:44The Mechanical Ventilation
  • 01:46Introduction of the Pulmonary Artery Catheter
  • 02:46Surfactant Depletion
  • 03:41Injurious Ventilation with High Tidal Volume/Low PEEP (High Tv/low PEEP)
  • 04:25Results: Effects of the Injurious Ventilation on the Lungs
  • 05:40Conclusion

Summary

자동 번역

使用 0.9% 盐水(35 mL/kg 体重,37 °C)和高潮汐量通风与低 PEEP 相结合,导致中度呼吸机诱发肺损伤 (VILI) 导致实验性急性呼吸窘迫综合征 (ARDS)。该方法提供了肺损伤模型,具有低/有限可招募性,可长期研究各种通气策略的效果。

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