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Chapters
- 00:05Introduction
- 00:45Spherical Polymersome Formation Using a Solvent Injection Method
- 02:24Dialysis to Remove Organic Solvent
- 03:05Dialysis Against Salt Gradients and Shape Modulated Polymersome Characterization
- 03:50Results: Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
- 05:36Conclusion
Polymersomes are self-assembled polymeric vesicles that are formed in spherical shapes to minimize Gibb's Free Energy. In the case of drug delivery, more elongated structures are beneficial. This protocol establishes methods to create more rod-like polymersomes, with elongated aspect ratios, using salt to induce osmotic pressure and reduce internal vesicle volumes.
