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Analyse af Parkinsons sygdom musemodel induceret af Adeno-associerede virale vektorer, der koder for humane α-synuclein
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Analyzing the Parkinson’s Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Analyse af Parkinsons sygdom musemodel induceret af Adeno-associerede virale vektorer, der koder for humane α-synuclein

DOI:
10.3791/63313-v

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14:45 min

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July 29, 2022

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, , , , , ,
1Laboratorio de Neuroinmunología,Fundación Ciencia & Vida, 2Center for Integrative Biology,Universidad Mayor, 3FONDAP Geroscience Center for Brain Health and Metabolism, 4Buck Institute for Research on Ageing, 5Facultad de Medicina y Ciencia,Universidad San Sebastián

Chapters

  • 00:13Introduction
  • 02:25The Stereotaxic Surgery
  • 05:38Determination of the Motor Performance Using the Beam Test
  • 07:00Tissue Processing
  • 08:51Representative Results
  • 12:59Conclusion

Summary

자동 번역

자동 번역

Dette arbejde analyserer vektordosis og eksponeringstid, der kræves for at inducere neuroinflammation, neurodegeneration og motorisk svækkelse i denne prækliniske model af Parkinsons sygdom. Disse vektorer, der koder for den humane α-synuclein, leveres i substantia nigra for at rekapitulere synucleinpatologien forbundet med Parkinsons sygdom.

Tags

Parkinson’s DiseaseMouse ModelAdeno-associated Viral VectorsHuman α-synucleinStereotaxic DeliveryNigrostriatal PathwayNeurodegenerationNeuroinflammationMotor ImpairmentSynuclein PathologyMicroglial ActivationT-cell ActivationAseptic EnvironmentAnalgesiaAnesthesia

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