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A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
 

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Article DOI: 10.3791/63657-v 08:05 min March 23rd, 2022
March 23rd, 2022

챕터

요약

A procedure that demonstrates a robust acute food deprivation-induced relapse to heroin seeking after punishment-imposed abstinence is described. A punishment-imposed abstinence model was successfully implemented using the seek and take chain schedule for heroin self-administration. Heroin-seeking tests are then performed following 24 h of food-deprivation stress.

Tags

Keywords: Stress-induced Relapse Heroin Seeking Punishment-imposed Abstinence Operant Conditioning Chambers Self-administration Seek-take Chain Fixed Ratio One Heroin Infusion Intertrial Interval Ecological Validity
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