Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Lingfeng Qin; Bo Jiang; Krisztina Zsebo; Henricus J. Duckers; Michael Simons; Pei-Yu Chen

doi:10.3791/63839

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Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

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Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

DOI:

10.3791/63839-v

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08:51 min

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November 11, 2022

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Lingfeng Qin, Bo Jiang, Krisztina Zsebo, Henricus J. Duckers, Michael Simons⁵, Pei-Yu Chen

¹Department of Surgery,Yale University School of Medicine, ²Department of Vascular Surgery,The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, ³VasoRx Inc., ⁴Yale Cardiovascular Research Center, Department of Internal Medicine,Yale University School of Medicine, ⁵Department of Cell Biology,Yale University School of Medicine

Summary

자동 번역

This protocol provides a step-by-step procedure for executing multiple intravenous bolus dose administration and invasive hemodynamic monitoring in mice. Investigators can use this protocol for future therapeutic compound screening for pulmonary artery hypertension.

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

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Summary

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