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加速性骨关节炎内侧半月板和软骨划痕鼠模型的不稳定
JoVE 신문
의학
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JoVE 신문 의학
Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
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加速性骨关节炎内侧半月板和软骨划痕鼠模型的不稳定

DOI:
10.3791/64159-v

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07:06 min

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July 06, 2022

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, , , ,
1Institute of Biomedical and Environmental Health Research,University of the West of Scotland, 2Institute of Infection, Immunity and Inflammation,University of Glasgow

Chapters

  • 00:05Introduction
  • 01:08Pre-Operative Care
  • 02:21Destabilization of the Medial Meniscus Procedure Followed by Cartilage Scratch
  • 04:16Post-Operative Care and Evaluation of Osteoarthritic Disease
  • 05:29Results: Destabilization of the Medial Meniscus and Cartilage Scratch Model to Study Post-Traumatic Osteoarthritis
  • 06:24Conclusion

Summary

자동 번역

자동 번역

本协议描述了通过切割内侧小肩韧带破坏小鼠膝盖稳定性后关节软骨表面上受控的微刀片划痕。该动物模型呈现了一种加速形式的骨关节炎（OA），适用于研究骨赘形成，骨硬化和早期疼痛。

Tags

MeniscusCartilageOsteoarthritisMouse ModelPost-traumaticOsteophyteEndochondral OssificationPainMedial Meniscotibial LigamentSurgeryAnesthesiaAnalgesiaPatellar LigamentJoint Capsule

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