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Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
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Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

DOI:
10.3791/64314-v

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06:29 min

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October 20, 2023

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, , ,
1Animal Surgery and Resources Core, National Heart, Lung, and Blood Institute,National Institutes of Health, 2College of Veterinary Medicine,Mississippi State University, 3Division of Veterinary Resources, Office of Research Services,National Institutes of Health

Chapters

  • 00:00Introduction
  • 00:05Surgical Setup and Animal Preparation
  • 01:29Surgery and Ischemia
  • 03:56Tissue Collection and Processing for Histology
  • 05:47Results: Post-IRI Analysis of Small Intestine

Summary

자동 번역

자동 번역

We describe how to generate a widely used surgical model of intestinal ischemia-reperfusion injury (IRI) in rodents. The procedure involves occlusion of the superior mesenteric artery followed by the restoration of blood flow. This model is useful for studies investigating occlusive causes of intestinal IRI in both veterinary and human medicine.

Tags

Rodent ModelIntestinal Ischemia-reperfusion InjurySuperior Mesenteric Artery OcclusionAnesthesiaBuprenorphineHeparinAbdominal IncisionSuperior Mesenteric ArteryIschemiaReperfusion

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