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1UNC Eshelman School of Pharmacy,University of North Carolina at Chapel Hill, 2Department of Biochemistry & Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences,The University of Melbourne, 3Department of Microbiology & Immunology,University of North Carolina School of Medicine, 4Department of Surgery,University of North Carolina at Chapel Hill, 5Curriculum in Toxicology and Environmental Medicine,University of North Carolina at Chapel Hill, 6Department of Microbiology, Monash Biomedicine Discovery Institute,Monash University
Chapters
- 00:05Introduction
- 00:57Preparing Rats for the Burn Injury
- 01:54Inducing the Burn Injury in Rats
- 03:20Preparation of Bacterial Inoculum and Infection
- 04:26Evaluation of the Burn Injury and Postprocessing of Rat Samples and Bacterial Enumeration
- 05:37Results: A Simple and Reproducible Rat Burn Infection Model
- 07:59Conclusion
يعد النموذج الذي يحاكي السيناريو السريري لإصابة الحروق والعدوى ضروريا لتعزيز أبحاث الحروق. يوضح البروتوكول الحالي نموذجا بسيطا وقابلا للتكرار لعدوى حرق الفئران يمكن مقارنته بنظيره الموجود في البشر. هذا يسهل دراسة الحروق والالتهابات بعد الحرق لتطوير علاجات المضادات الحيوية الموضعية الجديدة.
