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Chapters
- 00:04Introduction
- 01:23Surgical Area and Mouse Preparation
- 03:34Cell Injection, Needle Removal, and Wound Closure
- 05:53Results: Assessment of an Orthotopic Mouse Tumor Model for Human Glioblastoma Multiforme
- 06:55Conclusion
Here, we describe a preclinical orthotopic mouse model for GBM, established by intracranial injection of cells derived from genetically engineered mouse model tumors. This model displays the disease hallmarks of human GBM. For translational studies, the mouse brain tumor is tracked by in vivo MRI and histopathology.
