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使用急性淋巴细胞白血病患者来源的异种移植小鼠模型评估嵌合抗原受体T细胞相关毒性

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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

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使用急性淋巴细胞白血病患者来源的异种移植小鼠模型评估嵌合抗原受体T细胞相关毒性

DOI:

10.3791/64535-v

•

06:08 min

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February 10, 2023

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Claudia Manriquez Roman^2,3,4,5, R. Leo Sakemura², Brooke L. Kimball², Fang Jin, Roman H. Khadka, Mohamad M. Adada², Elizabeth L. Siegler², Aaron J. Johnson, Saad S. Kenderian^2,6

¹T Cell Engineering Laboratory,Mayo Clinic, Rochester, ²Division of Hematology,Mayo Clinic, Rochester, ³Mayo Clinic Graduate School of Biomedical Sciences,Mayo Clinic, Rochester, ⁴Department of Molecular Medicine,Mayo Clinic, Rochester, ⁵Regenerative Sciences PhD Program,Mayo Clinic, Rochester, ⁶Department of Immunology,Mayo Clinic, Rochester

Chapters

00:04Introduction
00:49Assessment of CART19 Cell‐Associated Toxicities
01:33MRI Imaging
04:02Results: Assessment of CART Cell‐Associated Toxicities in a PDX Mice Model
05:17Conclusion

Summary

자동 번역

在这里，我们描述了一种方案，其中使用急性淋巴细胞白血病患者来源的异种移植模型作为评估和监测CD19靶向嵌合抗原受体T细胞相关毒性的策略。

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Keywords: CAR-T Acute Lymphoblastic Leukemia Patient-derived Xenograft Toxicity Assessment Motor Weakness Weight Loss Cytokine Analysis MRI Imaging Breathing Monitoring ParaVision Software

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