JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
1Department of Pharmacology, College of Medicine,The University of Arizona, Tucson, 2Department of Anesthesiology, College of Medicine,The University of Arizona, Tucson, 3Neuroscience Graduate Interdisciplinary Program, College of Medicine,The University of Arizona, Tucson, 4Comprehensive Pain and Addiction Center,The University of Arizona, Tucson, 5Department of Anesthesiology and Pain Management,University of Texas Southwestern Medical Center
Chapters
- 00:05Introduction
- 00:57First Step: Measure the Baseline of Mechanical Sensitivity Using the Von Frey Test
- 01:53Second Step: Measure the Baseline of Thermal Sensitivity Using the Hargreaves Test
- 02:41Measuring the Baseline of Thermal Sensitivity Using the Hot Plate Test
- 03:47Preoperative Preparation
- 04:30Surgical Procedure and Postsurgical Behavioral Tests
- 06:38Results: Dose‐Dependent Reversal of pSNL‐Induced Mechanical Hypersensitivity by Intraperitoneal Injection of Morphine or Ibuprofen
- 07:36Conclusion
Delvis iskiasnerveligering inducerer langvarig kronisk neuropatisk smerte, karakteriseret ved overdrevne reaktioner på termiske og mekaniske stimuli. Denne musemodel af neuropatisk smerte bruges almindeligvis til at studere innovative terapier til smertebehandling. Denne artikel beskriver detaljeret den kirurgiske procedure for at forbedre standardisering og reproducerbarhed.
