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1Department of Pharmacology, College of Medicine,The University of Arizona, Tucson, 2Department of Anesthesiology, College of Medicine,The University of Arizona, Tucson, 3Neuroscience Graduate Interdisciplinary Program, College of Medicine,The University of Arizona, Tucson, 4Comprehensive Pain and Addiction Center,The University of Arizona, Tucson, 5Department of Anesthesiology and Pain Management,University of Texas Southwestern Medical Center
Chapters
- 00:05Introduction
- 00:57First Step: Measure the Baseline of Mechanical Sensitivity Using the Von Frey Test
- 01:53Second Step: Measure the Baseline of Thermal Sensitivity Using the Hargreaves Test
- 02:41Measuring the Baseline of Thermal Sensitivity Using the Hot Plate Test
- 03:47Preoperative Preparation
- 04:30Surgical Procedure and Postsurgical Behavioral Tests
- 06:38Results: Dose‐Dependent Reversal of pSNL‐Induced Mechanical Hypersensitivity by Intraperitoneal Injection of Morphine or Ibuprofen
- 07:36Conclusion
Die partielle Ligatur des Ischiasnervs induziert lang anhaltende chronische neuropathische Schmerzen, die durch übertriebene Reaktionen auf thermische und mechanische Reize gekennzeichnet sind. Dieses Mausmodell für neuropathische Schmerzen wird häufig verwendet, um innovative Therapien zur Schmerzbehandlung zu untersuchen. Dieser Artikel beschreibt detailliert das chirurgische Verfahren zur Verbesserung der Standardisierung und Reproduzierbarkeit.
