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Chapters
- 00:05Introduction
- 00:49Sciatic Nerve Preparation and Refurbishment
- 02:18Enzymatic Digestion of the Sciatic Nerve
- 03:04Cell Separation
- 03:59Schwann Cell Magnetic Separation
- 04:56Dorsal Root Ganglia (DRG) Preparation
- 06:04DRG Cell Culture and Coculture with Schwann Cells
- 07:13Results: Myelination in Coculture of DRG Explants and Schwann Cells
- 08:17Conclusion
In the coculture system of dorsal root ganglia and Schwann cells, myelination of the peripheral nervous system can be studied. This model provides experimental opportunities to observe and quantify peripheral myelination and to study the effects of compounds of interest on the myelin sheath.
