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1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education,Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes,Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center,Anhui University of Science and Technology
Chapters
- 00:04Introduction
- 00:37Preparation of Silica Suspension and Injection
- 01:44Mouse Capture and Nicotine Exposure
- 02:44Harvesting Fresh and Fixed Lung Tissues
- 04:35Results: Analysis of Nicotine‐Silica Exposed Mice s Lung Tissue
- 05:42Conclusion
This study describes a mouse model to study the synergistic effect of nicotine on the progression of pulmonary fibrosis in experimental silicosis mice. The dual-exposure mouse model simulates the pathological progression in the lung after simultaneous exposure to nicotine and silica. The methods described are simple and highly reproducible.
