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Journal / Biology / Application of a C. elegans Dopamine Neuron…
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JoVE Journal Biology
Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
 
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Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Article DOI: 10.3791/835-v • 08:42 min • July 18th, 2008
July 18th, 2008 •
1, 1, 1, 1, 1, 1
1Department of Biological Sciences, University of Alabama

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This video demonstrates how to use C. elegans to assess dopaminergic neuron neurodegeneration as a model for Parkinson's disease. Furthermore, genetic screens are used to identify factors that either enhance degeneration or are neuroprotective.

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C. Elegans Dopamine Neuron Degeneration Assay Parkinson's Disease Genes Diagnosis Treatment Susceptibility Factors Candidate Genes Polymorphisms Proteins Animal Model System Caenorhabditis Elegans Dopamine Neurons Alpha-synuclein Neurodegeneration GFP DA Transporter Promoter (Pdat-1) TorsinA RNAi
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