An <em>Ex Vivo</em> Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices

V. Reed LaSala; Halil Beqaj; Mingze Sun; Sabrina Castagnini; Senay Ustunel; Elizabeth Cordoves; Kavya Rajesh; Sophia Jackman; David Kalfa

doi:10.3791/65885

Evaluation of Hydrodynamic Properties in Mounted Porcine Aortic Valves

August 25, 2023

Advancing Cardiac Procedure Testing Prior to Embarking on Large Animal Studies (Video) | JoVE

01:05 min

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Preparation of Left Ventricular Outflow Tract (LVOT) from Porcine Heart for Cannulation (Video) | JoVE

02:21 min

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Mounting a Porcine Aortic Valve on a Pulse Duplicator for Testing Hydrodynamic Properties (Video) | JoVE

03:36 min

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V. Reed LaSala, Halil Beqaj, Mingze Sun, Sabrina Castagnini, Senay Ustunel, Elizabeth Cordoves, Kavya Rajesh, Sophia Jackman, David Kalfa⁴

¹Department of Surgery,Columbia University Medical Center, ²College of Physicians and Surgeons,Columbia University, ³School of Medicine and Surgery,University of Bologna, ⁴Division of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children’s Hospital,Columbia University Medical Center

Summary

We present a method for mounting a porcine aortic valve on a pulse duplicator to test its hydrodynamic properties. This method can be used to determine the change in hydrodynamics after the application of an experimental procedure or novel medical device prior to use in a large animal model.

Evaluation of Hydrodynamic Properties in Mounted Porcine Aortic Valves

Advancing Cardiac Procedure Testing Prior to Embarking on Large Animal Studies (Video) | JoVE

Preparation of Left Ventricular Outflow Tract (LVOT) from Porcine Heart for Cannulation (Video) | JoVE

Mounting a Porcine Aortic Valve on a Pulse Duplicator for Testing Hydrodynamic Properties (Video) | JoVE

Summary

Article