Streamlined Protocol for Mouse CAR-T Cell Generation in Syngeneic Models

February 02, 2024

小鼠嵌合抗原受体（CAR）-T细胞的高效生成

小鼠T细胞的转染和转导用于CAR-T细胞生成

Rosa L. Vincent, Fangda Li, Edward R. Ballister, Nicholas Arpaia³, Tal Danino^3,4

¹Department of Biomedical Engineering,Columbia University, ²Department of Microbiology & Immunology, Vagelos College of Physicians and Surgeons,Columbia University, ³Herbert Irving Comprehensive Cancer Center,Columbia University, ⁴Data Science Institute,Columbia University

Summary

该方案简化了逆转录病毒载体的产生和小鼠T细胞的转导，促进了小鼠CAR-T细胞的高效生成。

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